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Cardiovascular

Long-Lasting RNAi Therapeutics Targeting Angiotensinogen Induces a Robust and Durable Antihypertensive Effect

Estrellita Uijl, Katrina M. Mirabito Colafella, Ewout J. Hoorn, Jae B. Kim, Donald J. Foster, Alexander H. Danser, “Long-Lasting RNAi Therapeutics Targeting Angiotensinogen Induces a Robust and Durable Antihypertensive Effect,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-PO346 2018.

The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk

Eva-Maria Pastor-Arroyo, Nicole Gehring, Christiane Krudewig, Sarah Costantino, Carla Bettoni, Thomas Knöpfel, Sibylle Sabrautzki, Bettina Lorenz-Depiereux, Johanne Pastor, Tim M. Strom, Martin Hrabě de Angelis, Giovanni G. Camici, Francesco Paneni, Carsten A. Wagner, Isabel Rubio-Aliaga, “The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk,” Kidney Int. 2018 Jul;94(1):49-59. doi: 10.1016/j.kint.2018.02.017. Epub 2018 May 5.

Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation

Gregory J. Weber, Jaleyea Foster, Sathnur B. Pushpakumar, Utpal Sen, “Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation,” Department of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States Received 22 May 2018, Accepted 13 June 2018, Available online 15 June 2018, Pharmacological Research. https://doi.org/10.1016/j.phrs.2018.06.012.

AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats

Cunningham MW Jr, Castillo J, Ibrahim T, Cornelius DC, Campbell N, Amaral L, Vaka VR, Usry N, Williams JM, LaMarca B, “ AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats,” Hypertension. 2018 May;71(5):886-893. doi: 10.1161/HYPERTENSIONAHA.117.10681.

Renal Fibrosis and Tubular Transport Adaptation Caused by Cardiac Arrest and Cardiopulmonary Resuscitation (CA/CPR) in Mice

Michael Hutchens, Rumie Wakasaki, Ian P. Coe,Mohammed Z. Ferdaus, James A. McCormick, Sharon Anderson, “Renal Fibrosis and Tubular Transport Adaptation Caused by Cardiac Arrest and Cardiopulmonary Resuscitation (CA/CPR) in Mice,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO45 2017.

Intrauterine Growth Restriction Programs a Greater Age-related Decline in Renal Function Associated With Increased Susceptibility to Chronic Renal Injury

Ashley D Newsome, Gwendolyn K Davis, Norma B Ojeda, Barbara T Alexander, “ Intrauterine Growth Restriction Programs a Greater Age-related Decline in Renal Function Associated With Increased Susceptibility to Chronic Renal Injury” American Heart Association Journals – Hypertension, Hypertension. 2017;70:AP137.

Combined AT2 Receptor Stimulation AT1 Receptor Blockade Does Not Cause Renal Dysfunction

Dhaniel Baraldi, Lucinda M Hilliard, Tracey A Gaspari, Kate M Denton, Robert E Widdop, “Combined AT2 Receptor Stimulation AT1 Receptor Blockade Does Not Cause Renal Dysfunction” American Heart Association Journals – Hypertension, Hypertension. 2017;70:A016.

Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats

Nina D. Paauw, Jaap A Joles, Frank T. Spradley, Bhavisha Bakrania, Zsuzsanna K Zellenger, Arie Franx, Marianne C. Verhaar, Joey P. Granger, A. Titia Lely, “Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats,” American Journal of Physiology – Regulatory, Integrative and Comparative Physiology Published 15 February 2017 Vol. no. , DOI: 10.1152/ajpregu.00510.2016.

Intrarenal ACE as a Catalyst for Hypertension

Gonzales-Villaobos R.A., “Intrarenal ACE as a Catalyst for Hypertension,” J. Am. Soc. Nephrol. Kidney Week 2016.

Chronic recurrent dehydration associated with periodic water intake exacerbates hypertension and promotes renal damage in male spontaneously hypertensive rats

Hilliard LM, Colafella KM, Bulmer LL, Puelles VG, Singh RR, Ow CP, Gaspari T, Drummond GR, Evans RG, Vinh A, Denton KM, “Chronic recurrent dehydration associated with periodic water intake exacerbates hypertension and promotes renal damage in male spontaneously hypertensive rats,” Sci Rep. 2016 Sep 22;6:33855. doi: 10.1038/srep33855.

Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension

Spradley FT, Tan AY, Joo WS, Daniels G, Kussie P, Karumanchi SA, Granger JP.,“Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension,” Hypertension. 2016 Apr;67(4):740-7. doi: 10.1161/HYPERTENSIONAHA.115.06783. Epub 2016 Feb 1.

Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice

SR Mulay, Eberhard JN, Pfann V. et al,“Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice,” Am J Physiol Renal Physiol; Epub ahead of print Jan 13th 2016.

Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Convertin Enzyme

Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA, “Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Convertin Enzyme.,”  2015 Jul 6. Epub ahead of print.

Diabetes

Renal Olfactory Receptor 1393 Contributes to the Progression of Type II Diabetes in a Diet-Induced Obesity Model

Blythe D Shepard, Hermann Koepsell, and Jennifer L. Pluznick, “Renal Olfactory Receptor 1393 Contributes to the Progression of Type II Diabetes in a Diet-Induced Obesity Model,” Am. Journal of Physiology – Renal Physiology, 28 NOV 2018, https://doi.org/10.1152/ajprenal.00069.2018.

Glomerular Injury and Progressive Cardiac Dysfunction in the Obese ZSF1 Rat, a New Model of Diabetic Nephropathy and Heart Failure with Preserved Ejection Fraction

Elyse Di marco, Erik Michaëlsson, Charlotte Ericson, Margareta Behrendt, Maria Stromstedt, Magnus Soderberg, Johannes Wikstrom, Anna Granqvist, “Glomerular Injury and Progressive Cardiac Dysfunction in the Obese ZSF1 Rat, a New Model of Diabetic Nephropathy and Heart Failure with Preserved Ejection Fraction,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO106 2018.

Dapagliflozin Reduces Glomerular Hyperfiltration and Improves Urine Parameters in db/db Mice on High Protein Diet: A 4-week Model of Diabetic Nephropathy

Francois Briand, Sisse A. Nørgaard, Noémie Burr, Clément Costard, Emmanuel Brousseau, Nourdine Faresse, Fredrik Wolfhagen Sand, Thierry Sulpice, “Dapagliflozin Reduces Glomerular Hyperfiltration and Improves Urine Parameters in db/db Mice on High Protein Diet: A 4-week Model of Diabetic Nephropathy,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO112 2018.

The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease

Masahiro Eriguchi, Ellen A. Bernstein, Luciana C. Veiras, Zakir Khan, Duo Yao Cao, Sebastien Fuchs, Alicia A. McDonough, Jorge E. Toblli, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein and Jorge F. Giani, “The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease,” J Am Soc Nephrol. 2018 Sep 5. pii: ASN.2018030323. doi: 10.1681 / ASN.2018030323. [Epub ahead of print].

Losartan improves renal function and pathology in obese ZSF-1 rats

Zhi Su, Deborah Widomski, Artur Nikkel, Laura Lets, Marian Namovic, Diana Donnelly-Roberts, Murall Gopalakrishnan, Steve McGaraughty, “Losartan improves renal function and pathology in obese ZSF-1 rats,” Journal of Basic and Clinical Physiology and Pharmacology, Published Online: 2018-02-05 | DOI: https://doi.org/10.1515/jbcpp-2017-0157.

Renal Tubular ACE-Mediated Tubular Injury is The Major Contributor to Microalbuminuria in Early Diabetic Nephropathy

Masahiro Eriguchi, Mercury Lin, Michifumi Yamashita, Tuantuan V. Zhao, Zakir Khan, Ellen A. Bernstein, Susan B Gurley, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein, Jorge Fernando Giani, “Renal Tubular ACE-Mediated Tubular Injury is The Major Contributor to Microalbuminuria in Early Diabetic Nephropathy,” American Journal of Physiology – Renal Physiology Published 29 November 2017 Vol. no. , DOI: 10.1152/ajprenal.00523.2017.

Transcutaneous Measurement of Glomerular Filtration Rate in a Mouse Model of Diabetic Kidney Disease

Asim B. Dey, Leah L. Porras, Shannon M. Harlan, Josef G. Heuer, Mark Kowala, Matthew D. Breyer, Mark Rekhter, “Transcutaneous Measurement of Glomerular Filtration Rate in a Mouse Model of Diabetic Kidney Disease,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: PUB451 2017.

Renal Olfactory Receptor 1393 May Contribute to the Progression of Diabetic Nephropathy

Blythe D. Shepard and Jennifer L. Pluznick, “Renal Olfactory Receptor 1393 May Contribute to the Progression of Diabetic Nephropathy,” The FASEB Journal April 2017, vol. 31 no. 1 Supplement 716.4.

Vascular Actions of AT1 Angiotensin Receptors Do Not Contribute to Albuminuria or Hyperfiltration in Diabetic Kidney Disease

Sparks M. A., Johnson S. A., Gurley S. B., Thomas M. Coffman T M., “Vascular Actions of AT1 Angiotensin Receptors Do Not Contribute to Albuminuria or Hyperfiltration in Diabetic Kidney Disease,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-PO275 2016.

A Potent Pan-AMPK Activator Improves Renal Structure and Function in the ZSF-1 Rat Model of Diabetic Nephropathy

Hoek M., Zhou X., Haimbach R. E., Muise E., Ma L-J, Price O., Forrest G.M., Herath K., Zycband E., Ruben Z., Zhu Y., Pinto S., Kelley D. E., “A Potent Pan-AMPK Activator Improves Renal Structure and Function in the ZSF-1 Rat Model of Diabetic Nephropathy,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-OR055 2016.

Renal Tubular ACE Affects Microalbuminuria in Early Diabetic Nephropathy

Eriguchi M., Giani J.F., Lin M.Y., Zhao T., Khan Z., Bernstein E.A., Shen X., Gonzalez-Villalobos R.A., Bernstein K.E., “Renal Tubular ACE Affects Microalbuminuria in Early Diabetic Nephropathy,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-OR054 2016.

Renal Olfactory Receptor 1393 Contributes to Glucose Reabsorption

Shepard B. D., Cheval L., Zita P. L., Firestein S., Koepsel H., Doucet A., Pluznick J. L., “Renal Olfactory Receptor 1393 Contributes to Glucose Reabsorption,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-OR128 2016.

Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring

Hokke S., Arias N., Armitage J.A., Puelles V.G., Fong K., Geraci S., Gretz N., Bertram J.F., Cullen-McEwen L.A., “Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring,” Diabetes Metab Res Rev. 2016 Nov;32(8):816-826.

PBI-4425, A novel anti-inflamantory/fibrotic compound, improves kidney function and glomerular integrity in the diabetic DB/DB mouse mode

Lyne Gagnon, Kathy Hince, François Sarra-Bournet, Liette Gervais, Alexandra Felton, Alexandre Laverdure, William Gagnon, Martin Leduc, Lilianne Geerts, Pierre Laurin, Brigitte Grouix, “PBI-4425, A novel anti-inflamantory/fibrotic compound, improves kidney function and glomerular integrity in the diabetic DB/DB mouse mode,” ERA-EDTA 2016 conference abstract SO022.

A Longitudinal Study on Kidney Function, Pathology, and Multiple Urinary Biomarkers in ZSF1 Rat Model of Type II Diabetic Nephropathy

Z. Su, D. Widomski, M. T. Namovic, D. L. Donnelly‑Roberts, L. Leys, K. Salte, A. L. Nikkel, L. Olson, J. Ma, T. A.Esbenshade, S. McGaraughty, “A Longitudinal Study on Kidney Function, Pathology, and Multiple Urinary Biomarkers in ZSF1 Rat Model of Type II Diabetic Nephropathy,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 709A, 2015.

Losartan improves renal function and pathology in a rat model of type II diabetic nephropathy

Widomski D, Leys L, Larson K, McGaraughty S, Su Z, Nikkel AL, “Losartan improves renal function and pathology in a rat model of type II diabetic nephropathy,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (25): 1073A, 2014.

Immunology & Inflammation

Role of Adenosine 1a Receptor Signaling on GFR Early after the Induction of Sepsis

Street J, Koritzinsky E.H, Yuen P.S.T, Star R.A., “Role of Adenosine 1a Receptor Signaling on GFR Early after the Induction of Sepsis,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO106 2016.

Role of Interleukin 17 Receptor A in Enhanced Atherosclerotic Inflammation in Renal Impairment

Nordlohne J., Ge S., Waisman A., Haller H. G., Von Vietinghoff S., “Role of Interleukin 17 Receptor A in Enhanced Atherosclerotic Inflammation in Renal Impairment,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-OR TH-PO354 2016.

Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation

Andersen K, Kesper MS, Marschner JA, Konrad L, Ryu M, Kumar Vr S, Kulkarni OP, Mulay SR, Romoli S, Demleitner J, Schiller P, Dietrich A, Müller S, Gross O, Ruscheweyh HJ, Huson DH, Stecher B, Anders HJ, “Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation,” J Am Soc Nephrol 2016 May 5. pii: ASN.2015111285. [Epub ahead of print].

Sepsis Reduces Kidney Function in Mice Before Hemodynamic Alterations or Clinical Symptoms Become Apparent

J. Street, Y. G. Huang, P. S.T. Yuen, R. A. Star, “Sepsis Reduces Kidney Function in Mice Before Hemodynamic Alterations or Clinical Symptoms Become Apparent,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 94A, 2015.

GFR in Conscious Mice After Sepsis: Role of Tubuloglomerular Feedback

J. Street, Y. G. Huang, P. S.T. Yuen, R. A. Star, “GFR in Conscious Mice After Sepsis: Role of Tubuloglomerular Feedback,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 686A, 2015.

Human recombinant alkaline phosphatase protects against lipopolysaccharide-induced renal inflammation

Peters E, Gretz N, Pickers P, Masereeuw R, “Human recombinant alkaline phosphatase protects against lipopolysaccharide-induced renal inflammation,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (25): 147A, 2014.

Metabolism & Regulation

Microangiography Reveals the Protective Role of Liraglutide on Renal Microvascular Impairment in Rats with Metabolic Syndrome

Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Takashi Sonobe, Mikiyasu Shirai, James T. Pearson, “Microangiography Reveals the Protective Role of Liraglutide on Renal Microvascular Impairment in Rats with Metabolic Syndrome,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO856 2018.

De novo NAD+ synthesis enhances mitochondrial function and improves health

Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J, “De novo NAD+ synthesis enhances mitochondrial function and improves health,” Nature. 2018 Oct 24. doi: 10.1038/s41586-018-0645-6 [Epub ahead of print].

Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice

Kasztan M, Fox BM, Speed JS, De Miguel C, Gohar EY, Townes TM, Cutler A, Pollack DM, “Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice,” J. Am. Soc. Nephrol. 2017 Mar 27. [Epub ahead of print].

Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3

Li X, Knight J, Todd Lowther W, Holmes RP, “Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3,” Biochim Biophys Acta 2015 Sep 29. Epub ahead of print.

A western diet leading to maternal glucose intolerance and obesity elevates offspring nephron endowment without adverse effects on adult renal function

Hokke S, Armitage J, Pulles VG, Bertram JF, Cullen-McEwen LA, “A western diet leading to maternal glucose intolerance and obesity elevates offspring nephron endowment without adverse effects on adult renal function,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (25): 534A, 2014.

Renal

Ischemia Time Effects Long-Term Kidney Function in a Murine Model of Unilateral Ischemic AKI

Danielle Soranno, Lara A. Kirkbride-Romeo, Sarah Faubel, “Ischemia Time Effects Long-Term Kidney Function in a Murine Model of Unilateral Ischemic AKI,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO591 2018.

The Distribution Profile of Anti-Sense Oligonucleotides Indicates That Proximal Tubular Targets Should Be Prioritized in Renal Disease

Anna Granqvist, Lena William-Olsson, Barbro Basta, Charlotte Ericson, Pernilla Tonelius, Åsa Wåhlander, Thomas Bell, Patrik Andersson, Magnus Soderberg, Robert J. Unwin, Mark J. Anderton, Christine Ahlström, “The Distribution Profile of Anti-Sense Oligonucleotides Indicates That Proximal Tubular Targets Should Be Prioritized in Renal Disease,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO631 2018.

Genetic Nrf2 Enhancement Increases Proteinuric Renal Injury

Brittney M. Rush, Corry D. Bondi, Kacie Barry, Sean D. Stocker, Soma Jobbagy, Donna B. Stolz, Dionysios Chartoumpekis, Thomas W. Kensler, Roderick J. Tan, “Genetic Nrf2 Enhancement Increases Proteinuric Renal Injury,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO815 2018.

AMPK Deficiency Worsens Albuminuria Post Uninephrectomy (UNX)

Daniel Rivera, Roshan Rajani, Valeria Mancino, Parisa Rezapoor, Hamidreza Zohoorkari, Biagio Saitta, Pei-Yin Ho, Hui Li, Kenneth R. Hallows, Nuria M. Pastor-Soler, “AMPK Deficiency Worsens Albuminuria Post Uninephrectomy (UNX),” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO845 2018.

Varying Nephrectomy Delay Time After Unilateral Ischemic Injury Allows Development of an Animal Model with a Controllable Degree of Renal Dysfunction

Lies Moonen, Cristina Cuesta, Patrick C. D’Haese, Francisco J. Lopezhernandez, Carlos Martinez-salgado, Benjamin A. Vervaet, “Varying Nephrectomy Delay Time After Unilateral Ischemic Injury Allows Development of an Animal Model with a Controllable Degree of Renal Dysfunction,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: PUB-168 2018.

A New Mouse Model for Septic AKI with Vasopressor Support

Brianna C. Halasa, Jonathan Street, Peter S. Yuen, Robert A. Star, “A New Mouse Model for Septic AKI with Vasopressor Support,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-PO057 2018.

Megalin Deletion Prevents Long-Term Loss of Glomerular Filtration Rate After Rhabdomyolysis

Katsuyuki Matsushita, JamesA.McCormick, Kiyoshi Mori, Motoko Yanagita, Michael Hutchens, “Megalin Deletion Prevents Long-Term Loss of Glomerular Filtration Rate After Rhabdomyolysis,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-PO123 2018.

Extracellular DNA Drives Cholesterol Crystal Embolism-Related Tissue Injury

Chongxu Shi, Shrikant R. Mulay, Barbara M. Klinkhammer, Helen Liapis, Peter Boor, Hans J. Anders, “Extracellular DNA Drives Cholesterol Crystal Embolism-Related Tissue Injury,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-OR001 2018.

Long-Term Sequelae of AKI: A Year-Long Male and Female Murine Model

Danielle Soranno, Sarah Faubel, “Long-Term Sequelae of AKI: A Year-Long Male and Female Murine Model,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-OPO090 2018.

AKI to CKD Transition After Acute Cardiorenal Syndrome in the Mouse

Katsuyuki Matsushita, Turgay Saritas, James A. McCormick, Michael Hutchens, “AKI to CKD Transition After Acute Cardiorenal Syndrome in the Mouse,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO091 2018.

Using Transdermal Measurement of GFR to Evaluate Long-Term Outcomes in Mouse Models of AKI

Lauren N. Scarfe, Charlene Finney, Anna Menshikh, Rachel Delgado, Mark P. de Caestecker, “Using Transdermal Measurement of GFR to Evaluate Long-Term Outcomes in Mouse Models of AKI,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO094 2018.

Adipose-Derived Regenerative Cells: Therapeutic Potential

Rashida Lathan, Ryan Ghita, Patrick B. Mark, Marc J. Clancy, Rhian Touyz, Marc Clancy and Patrick Mark Team, “Adipose-Derived Regenerative Cells: Therapeutic Potential,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO638 2018.

Endogenous Pentraxin 3 Inhibits Nephrocalcinosis and Protects from Hyperoxaluria-Induced CKD

Julian A. Marschner, Shrikant R. Mulay, Lidia Anguiano, Stefanie Steiger, Antonio Inforzato Hans J. Anders, “Endogenous Pentraxin 3 Inhibits Nephrocalcinosis and Protects from Hyperoxaluria-Induced CKD,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO722 2018.

Divergent effects of AKI to CKD models on inflammation and fibrosis

Laurence Black, Jeremie M Lever, Amie M. Traylor, Bo Chen, Zhengqin Yang, Stephanie Esman, Yanlin Jiang, Gary Cutter, Ravindra Boddu, James George, and Anupam Agarwal, “Divergent effects of AKI to CKD models on inflammation and fibrosis,” American Journal of Physiology, Renal Physiology, https://doi.org/10.1152/ajprenal.00179.2018.

Tubular cell hypertrophy via endocycle and proliferation of tubular progenitors are central mechanisms of response after AKI

Elena Lazzeri, Maria Lucia Angelotti, Anna Julie Peired, Carolina Conte, Laura Lasagni, Paola Romagnani, “Tubular cell hypertrophy via endocycle and proliferation of tubular progenitors are central mechanisms of response after AKI,” University of Florence, Department of Biomedical Experimental and Clinical Sciences, Florence, Italy, ERA-EDTA meeting Copenhagen 2018 FP312.

Papillary renal cell carcinoma originates from a population of renal progenitor cells and is promoted by Acute Kidney Injury

Anna J. Peired, Giulia Antonelli, Maria Lucia Angelotti, Alessandro Sisti, Marco Allinovi, Maria Rosaria Raspollini, Paola Romagnani, “Papillary renal cell carcinoma originates from a population of renal progenitor cells and is promoted by Acute Kidney Injury,” University of Florence, Department of Experimental, Clinical and Biomedical Sciences “Mario Serio”, Florence, Italy, University Hospital Careggi, Histopathology and Molecular Diagnostics, Florence, Italy, Meyer Children’s University Hospital, Nephrology Unit, Florence, Italuy, ERA-EDTA meeting Copenhagen 2018 SaO032.

Endogenous pentraxin 3 inhibits nephrocalcinosis and protects from hyperoxalluria-induced Chronic Kidney Disease

Julian A. Marschner, Shrikant R. Mulay, Stefanie Steiger, Lidia Anguiano, Antonio Inforzato, Cecilia Garlanda, Mantovani Alberto, Hans-Joachim Anders, “Endogenous pentraxin 3 inhibits nephrocalcinosis and protects from hyperoxalluria-induced Chronic Kidney Disease,” Klinikum der Universität München, Medizinische Klinik und Poliklinik IV, Nephrologisches Zentrum, Munich, Germany, Istituto Clinico Humanitas (ICH) IRCCS, Laboratory of Immunopharmacology, Rozzano, Italy, ERA-EDTA meeting Copenhagen 2018 SuO027.

Macrophage polarization and granuloma formation in hyperuricemia-associated chronic kidney disease

Markus Sellmayr, Qiuyue Ma, Moritz R. Hernandez Petzsche, Vivianne Gnemmi, Hans-Joachim Anders, Stefanie Steiger, “Macrophage polarization and granuloma formation in hyperuricemia-associated chronic kidney disease,” Klinikum der Universität München, Medizinische Klinik und Poliklinik IV, Nephrologisches Zentrum, München, GERMANY, Klinikum der Universität München, Medizinische Klinik und Poliklinik IV, Nephrologisches Zentrum, Munich, GERMANY, Klinikum der Universtität München, Medizinische Klinik und Poliklinik IV, Nephrologisches Zentrum, Munich, Germany, ERA-EDTA meeting Copenhagen 2018 FP312.

Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury

Abdulmahdi W, Rabadi MM, Jules E, Marghani Y, Marji N, Leung J, Zhang FF, Siani A, Siskind T, Vedovino K, Chowdhury N, Sekulic M, Ratliff BB, “Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury,” Kidney Int. 2018 May;93(5):1131-1141. doi: 10.1016/j.kint.2017.11.018.

Kidney dysfunction in the low birth weight murine adult: implications of oxidative stress

Toro L, Barrientos V, León P, Rojas M, Gonzalez M, González-Ibáñez A, Illanes S, Sugikawa K, Abarzúa N, Bascuñán C, Arcos K, Fuentealba C, Tong AM, Elorza AA, Pinto ME, Alzamora R, Romero C, Michea L., “Kidney dysfunction in the low birth weight murine adult: implications of oxidative stress,” Am J Physiol Renal Physiol. 2018 May 30. doi: 10.1152/ajprenal.00164.2018.

Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats

Chang Z. Zhu, Kelly J. Doyle, Arthur L. Nikkel, Lauren Olsen, Marian T. Namovic, Katherine Salte, Deborah Widomski, Zhi Su, Diana L. Donnelly-Roberts, Murali M. Gopalakrishnan, Steve McGaraughty, “Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats,” Journal of Pharmacological and Toxicological Methods, https://doi.org/10.1016/j.vascn.2018.04.003.

Anti-Transforming Growth Factor β IgG Elicits a Dual Effect on Calcium Oxalate Crystallizationand Progressive Nephrocalcinosis-Related Chronic Kidney Disease

Stefanie Steiger, Julia Felicitas Grill, Qiuyue Ma, Tobias Bäuerle, Jutta Jordan, Michaela Smolle, Claudia Böhland, Maciej Lech and Hans-Joachim Anders, “Anti-Transforming Growth Factor β IgG Elicits a Dual Effect on Calcium Oxalate Crystallizationand Progressive Nephrocalcinosis-Related Chronic Kidney Disease,” Frontiers in Immunology March 2018, doi: 10.3389/fimmu.2018.00619.

Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response

Monica Chang-Panesso, Farid F. Kadyrov, Flavia G. Machado, Ashish Kumar, and Benjamin D. Humphreys, “Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response,” American Journal of Physiology 28 MAR 2018, https://doi.org/10.1152/ajprenal.00030.2018.

Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

Victoria Rado, Maire Czesla, Julia Reichelt, Julia Fehlert, Anna Hammel, Alva Rosendahl, Jan-Hendrik Knop, Thorsten Wiech, Ulrich O. Wenzel, Marlies Sachs, Anna T. Reinicke, Rolf A.K. Stahl and Catherine Meyer-Schwesinger, “Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney,” Kidney International (2018) 93, 110-127.

Novel Differences in Renal Gene Expression in a Diet Induced Obesity Model

Victoria L. Halperin Kuhns, Jennifer L. Pluznick, “Novel Differences in Renal Gene Expression in a Diet Induced Obesity Model,” American Journal of Physiology – Renal Physiology Published 15 November 2017 Vol. no. , DOI: 10.1152/ajprenal.00345.2017.

Gli1+ Pericytes Are Required for AKI Recovery and Regulate Renal Function

Flavia G. Machado, Eoghainín O. Hainmhire, Benjamin D. Humphreys, “Gli1+ Pericytes Are Required for AKI Recovery and Regulate Renal Function,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-OR087 2017.

The Impact of Uninephrectomy on Subsequent AKI Outcomes

Myunggyu Kim, Hiroshi Kojima, Jonathan Street, Erik H. Koritzinsky, Xuzhen Hu, Peter S. Yuen, Robert A. Star, “The Impact of Uninephrectomy on Subsequent AKI Outcomes,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO316 2017.

Endocycle-Mediated Hypertrophy and Progenitor Proliferation as Central Mechanisms of Response to AKI

Elena Lazzeri, Maria Lucia Angelotti, Anna J. Peired, Carolina Conte, Laura Lasagni, Paola Romagnani, “Endocycle-Mediated Hypertrophy and Progenitor Proliferation as Central Mechanisms of Response to AKI,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-OR085 2017.

Liraglutide Treatment Improves Renal Vascular Function in Zucker Rats as Visualized by Microangiography

Vijayakumar Sukumaran, Takashi Sonobe, Hirotsugu Tsuchimochi, Eisuke Tatsumi, Mikiyasu Shirai, James T. Pearson, “Liraglutide Treatment Improves Renal Vascular Function in Zucker Rats as Visualized by Microangiography,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-OR098 2017.

Tubule Specific Deletion of Cullin 3 Causes Cell Cycle Dysregulation and Kidney Fibrosis

Turgay Saritas, Catherina A. Cuevas, Christoph Kuppe, Rafael Kramann, Marcus J. Moeller, Jeffrey Singer, Jürgen Floege, James A. McCormick, “Tubule Specific Deletion of Cullin 3 Causes Cell Cycle Dysregulation and Kidney Fibrosis,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO353 2017.

Transcutaneous Glomerular Filtration Rate Measurement in a Canine Animal Model of Chronic Kidney Disease

Thomas Mondritzki, Sarah M.L. Steinbach, Philip Boehmea, Jessica Hoffmann, Maximilian Kullmann, Daniel Schock-Kusch, Julia Vogel, Peter Kolkhof, Peter Sandner, Erwin Bischoff, Jörg Hüser, Wilfried Dinh, Hubert Truebel, “Transcutaneous Glomerular Filtration Rate Measurement in a Canine Animal Model of Chronic Kidney Disease,” Journal of Pharmacological and Toxicological Methods
(2017) https://doi.org/10.1016/j.vascn.2017.10.009.

Low birth weight is associated with impaired murine kidney development and function

Christina Barnett, Oluwadara Nnoli, Wasan Abdulmahdi, Lauren Nesi, Michael Shen, Joseph A Zullo, David L Payne, Tala Azar, Parth Dwivedi, Kunzah Syed, Jonathan Gromis, Mark Lipphardt, Edson Jules, Eric L Maranda, Amy Patel, May M Rabadi, Brian B Ratliff, “Low birth weight is associated with impaired murine kidney development and function,” Pediatric Research (2017) doi:10.1038/pr.2017.53.

Anti-Histone IGG attenuates CKD upon AKI related to postischemic tubular necrosis in mice

Lukas Cath, Julianm Marschner, Alexander Holderied, Hans-Joachim Anders, “Anti-Histone IGG attenuates CKD upon AKI related to postischemic tubular necrosis in mice,” Nephrology Dialysis Transplatation (2017) 32 (suppl_3):iii512., DOI:https://doi.org/10.1093/ndt/gfx166.

Combining new tools to assess renal function and morphology: a holistic approach to study the effects of aging and a congenital nephron deficit

Stefania Geraci, Jorge Chacón-Caldera, Luise Anne Cullen-McEwen, Lothar R Schad, Carsten Sticht, Victor G Puelles, John F Bertram, Norbert Gretz, “Combining new tools to assess renal function and morphology: a holistic approach to study the effects of aging and a congenital nephron deficit,” American Journal of Physiology – Renal Physiology May 10, 2017, DOI:10.1152/ajprenal.00329.2015.

Intrauterine Growth Restriction Programs Greater Susceptibility to Chronic Kidney Injury in Male and Female Aged Rats

Ashley D. Newsome, Gwendolyn K. Davis and Barbara T. Alexander, “Intrauterine Growth Restriction Programs Greater Susceptibility to Chronic Kidney Injury in Male and Female Aged Rats,” The FASEB Journal April 2017, vol. 31 no. 1 Supplement 852.4.

The Effect Of Dietary Amino Acids On Chronic Kidney Disease Progression in Rats

Samyuktha Muralidharan Pillai and François Verrey, “The Effect Of Dietary Amino Acids On Chronic Kidney Disease Progression in Rats,” The FASEB Journal April 2017, vol. 31 no. 1 Supplement 1030.22.

Assessment of acute kidney injury in rhabdomyolytic mice by transcutaneous measurement of sinistrin excretion

Moggio A, Geraci S, Boido A, Sticht C, Gretz N, Bussolati B, “Assessment of acute kidney injury in rhabdomyolytic mice by transcutaneous measurement of sinistrin excretion,” Nephrol Dial Transplant. 2017 Feb 27. doi: 10.1093/ndt/gfw438. Epub ahead of print.

Murine Double Minute-2 Prevents Tubular Atrophy by Inhibiting p53 Overactivation-Dependent Cell Death (Podoptosis) in Tubular Cells

Thomasova D, Ebrahim M, Fleckinger K, Li M, Liapis H, Anders H. J., “Murine Double Minute-2 Prevents Tubular Atrophy by Inhibiting p53 Overactivation-Dependent Cell Death (Podoptosis) in Tubular Cells,” Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO360 2016.

Dietary Salt Impacts Active Sodium Transport and Metabolic Sensing along the Kidney Tubule

Udwan K., Abed A., Bettoni C., Roth I., Wagner C. A, Feraille E., “Dietary Salt Impacts Active Sodium Transport and Metabolic Sensing along the Kidney Tubule,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: SA-PO119 2016.

Tubular Cell Endocycle-Related Hypertrophy and Renal Progenitor Mitosis Drive Kidney Function Recovery after AKI but Cannot Avoid Persistent Tubular Cell Loss

Lazzeri E., Angelotti M. L., Peired A. L., Lombardi D., Becherucci F., Hans J., Anders H. J., Lasagni L., Romagnani P., “Tubular Cell Endocycle-Related Hypertrophy and Renal Progenitor Mitosis Drive Kidney Function Recovery after AKI but Cannot Avoid Persistent Tubular Cell Loss,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-PO317 2016.

The Role of IL-6 Signaling on the Transition of Acute Kidney Injury to Chronic Kidney Disease

Kim M-G., Kojima H., Street J., Hu X., Yuen P.S.T., Robert A. Star R.A., “The Role of IL-6 Signaling on the Transition of Acute Kidney Injury to Chronic Kidney Disease,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-PO275 2016.

Long-Term Selective ETA Receptor Antagonism Prevents Renal Injury in Humanized Sickle Cell Mice

Kasztan M., De Miguel C., Pollock S.J., Pollock D.M., “Long-Term Selective ETA Receptor Antagonism Prevents Renal Injury in Humanized Sickle Cell Mice,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: FR-PO182 2016.

Longitudinal Characterization of Glomerular Filtration Rate of the Naïve ZSF1 Rat

Haimbach R.E., Ma L-J, Hoek M., Pinto S., Zhou X., “Longitudinal Characterization of Glomerular Filtration Rate of the Naïve ZSF1 Rat,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO464 2016.

Adenine Overload Causes Severe AKI Progressing to CKD by Activation of Innate Immunity in Rats and Mice

Moreira G.C.S., Machado F.G., Fujihara C.K., Humphreys B.D., Zatz R., “Adenine Overload Causes Severe AKI Progressing to CKD by Activation of Innate Immunity in Rats and Mice,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO092 2016.

Transcutaneous Measurement of Glomerular Filtration Rate to Assess the Progression from Acute to Chronic Kidney Disease following Bilateral Ischemic Injury in Mice

Soranno D., Altmann C., Faubel S., “Transcutaneous Measurement of Glomerular Filtration Rate to Assess the Progression from Acute to Chronic Kidney Disease following Bilateral Ischemic Injury in Mice,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement: TH-PO085 2016.

Improved kinetic model for transcutaneous measurement of glomerular filtration rate in experimental animals

J. Friedemann, R. Heinrich, Y. Shulhevich, M. Raedle  J. Pill, D. Schock-Kusch, “Improved kinetic model for transcutaneous measurement of glomerular filtration rate in experimental animals,” Kidney int. In press, accepted for publication 14-Jul-2016 DOI: http://dx.doi.org/10.1016/j.kint.2016.07.024.

Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice

Hokke S, Puelles VG, Armitage JA,Fong K, Bertram JF, McEwen LA, “Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice,” PLoS One. 2016 Aug 22;11(8):e0161578. doi: 10.1371/journal.pone.0161578. eCollection 2016.

Beta-Hydroxybutyrate inhibits NLRP3-Mediated inflammation and delays progressive renal failure during primary hyperoxaluria related kidney stone Disease

Shrikant R. Mulay, Beatriz Suarez-Alvarez, Steffanie Steiger, Mohsen Honarpisheh, Julian Marschner, Jyaysi Desai, Hans-Joachim Anders, “Beta-Hydroxybutyrate inhibits NLRP3-Mediated inflammation and delays progressive renal failure during primary hyperoxaluria related kidney stone Disease,” ERA-EDTA 2016 conference abstract TO027.

Effect of Aging on Kidney Function in Male Intrauterine Growth Restricted Rats

Ashley Newsome, John Henry Dasinger, Suttira Intapad Gwen Davis and Barbara Alexander
April 2016 The FASEB Journal vol. 30 no. 1 Supplement 1214.6

An Aristolochic Acid-Induced Nephropathy (AAN) Model for Stable CKD in Mice

H. Kojima, X. Hu, Y. G. Huang, A. C. Souza, J. Street, P. S.T. Yuen, R. A. Star, ”An Aristolochic Acid-Induced Nephropathy (AAN) Model for Stable CKD in Mice,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 148A, 2015.

Analysis of Exogenous Near Infrared Fluorescent Markers fort he Transcutaneous Measurement of Glomerular Filtration Rate

J. Huang, S.  Weinfurter, J. Pill, N. Gretz, R. Perciaccante, F. Rodeghiero, L. Della Ciana, “Analysis of Exogenous Near Infrared Fluorescent Markers fort he Transcutaneous Measurement of Glomerular Filtration Rate,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 259A, 2015.

Studying the Effect of Induced Expandable Human Kidney Progenitor Cells on Renal Function Using Transcutaneous Assessment

Z. H. Perez, O. Pleniceanu, D. Omer, B. Dekel, N. Gretz,“Studying the Effect of Induced Expandable Human Kidney Progenitor Cells on Renal Function Using Transcutaneous Assessment,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 410A, 2015.

Longitudinal Transcutaneous Glomerular Filtration Rate (GFR) After Uninephrectomy (UNx) in Mice

H. Kojima, J. Street, A. C. Souza, P. S.T. Yuen, R. A. Star, “Longitudinal Transcutaneous Glomerular Filtration Rate (GFR) After Uninephrectomy (UNx) in Mice,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 728A, 2015.

SLIT2 Is Upregulated in Proximal Tubules and Urine following Folic Acid Induced Kidney Injury

J. Street, A. C. Souza, X. Hu, Y. G. Huang, P. S.T. Yuen, R.A. Star, “SLIT2 Is Upregulated in Proximal Tubules and Urine following Folic Acid Induced Kidney Injury,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (26): 978A, 2015.

A Novel Analysis Technique for Transcutaneous Measurement of Glomerular Filtration Rate With Ultralow Dose Marker Concentrations

Shmarlouski A, Schock-Kusch D, Shulhevich Y, Buschmann V, Rohlicke T, Herdt D, Radle M, Hesser J, Stsepankou D, “A Novel Analysis Technique for Transcutaneous Measurement of Glomerular Filtration Rate With Ultralow Dose Marker Concentrations,” IEEE Trans Biomed Eng. 2016 Aug;63(8):1742-50.

Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments

Baisantry A,  Bhayana S, Rong S, Ermeling E, Wrede C, Hegermann J, Pennekamp P, Sörensen-Zender I, Haller H,  Melk A, Schmitt R,”Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments,” J Am Soc Nephrol.2015 Oct 20. pii: ASN.2014111059. [Epub ahead of print]

Non–Invasive GFR assessment in conscious rats with puromycin induced nephropathy

William-Olsson L, Lagerkvist U, Ericson C, Hermansson M, Ericsson AE, Granquist A,”Non–Invasive GFR assessment in conscious rats with puromycin induced nephropathy,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (25): 392A, 2014.

Ablation of Proximal Tubular Autophagy Prevents Senescence and Fibrosis after Acute Kidney Injury

Baisantry A, Bhayana S, Rong S, Haller HG, Melk A, Schmitt R, “Ablation of Proximal Tubular Autophagy Prevents Senescence and Fibrosis after Acute Kidney Injury,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (25): 527A, 2014.

Endotoxemia-induced decrease in GFR is mediated in part by COX-1 derived prostanoids in mice

Höcherl K, “Endotoxemia-induced decrease in GFR is mediated in part by COX-1 derived prostanoids in mice,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement  (25): 149A, 2014

A Renal olfactory receptor aids in glucose handling in the proximal tubule

Shephard BD, Cheval L, Doucet A, Pluznick JL, “A Renal olfactory receptor aids in glucose handling in the proximal tubule,” J. Am. Soc. Nephrol. Kidney Week Abstract Supplement (25): 102A, 2014.

Automatic artifact removal from GFR measurements

Shmarlouski A, Shulhevich Y, Geraci S, Friedemann J, Gretz N, Neudecker S, Hesser J. Stsepankou D, “Automatic artifact removal from GFR measurements,” Biomed Signal Process Control., November 2014, Pages 30–4.

Transcutaneous assessment of glomerular filtration rate

Geraci S, Herrera-Pérez Z, Huang J, Weinfurter S, Neudecker S, Shulhevich Y, Friedemann J, Pill J, Gretz N, ”Transcutaneous assessment of glomerular filtration rate,” Stud Health Technol Inform 2014;200:105-10.

Online feedback-controlled renal constant infusion clearances in rats

Schock-Kusch D, Shulhevich Y, Xie Q, Hesser J, Stsepankou D, Neudecker S, Friedemann J, Koenig S, Heinrich R, Hoecklin F, Pill J, Gretz N, “Online feedback-controlled renal constant infusion clearances in rats,” Kidney Int. 82(3): 314–20, 2012.

Two non-invasive GFR-estimation methods in rat models of polycystic kidney disease: 3.0 Tesla dynamic contrast enhanced MRI and optical imaging

Sadick M, Attenberger U, Kraenzlin B, Kayed H, Schoenberg SO, Gretz N, Schock-Kusch D, “Two non-invasive GFR-estimation methods in rat models of polycystic kidney disease: 3.0 Tesla dynamic contrast enhanced MRI and optical imaging,” Nephrol. Dial. Transplant. 26(10): 3101–8, 2011

Toxicology

Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies

Benjamin A, Gallacher DJ, Greiter-Wilke A, Guillon J, Kasai C, Ledieu D, Levesque P, Prelle K, Ratcliffe S, Sannajust F, Valentin J, “Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies,” J. Pharmacol Toxicol Methods, 2015 Sept-Oct; 7: 101-10.

This device is not approved for human use.