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Life, illuminated.
Advancing fluorescent technology to help improve patient care.

MediBeacon is a medical technology company specializing in the advances of fluorescent tracer agents and transdermal measurement. The science is complex, but the outcomes are simple to understand. How it works >>

PRECLINICAL
MediBeacon technology is available for preclinical use.
CLINICAL
MediBeacon technologies are progressing through clinical trials.*
Focused on Providing Kidney Insights to Clinicians

The MediBeacon Transdermal GFR System (TGFR) is engineered to allow detection of the change in patient levels of a fluorescent GFR tracer agent over time via a sensor placed on the patient’s skin. The rate of decrease in the emitted fluorescence from Lumitrace® is automatically calculated and displayed on the monitor and is intended to provide information regarding the rate of clearance of Lumitrace injection which may be useful in the understanding of kidney function. The TGFR Monitor displays this information in the form of a transdermal GFR (tGFR).

The MediBeacon TGFR includes, Lumitrace (relmapirazin), a fluorescent GFR tracer agent administered as an IV bolus injection.

The TGFR Sensor is engineered to non-invasively measure the intensity of the Lumitrace 2.5 times per second. The rate of decrease of Lumitrace fluorescence measured on the skin is being shown in clinical studies to be highly correlated with measured GFR (mGFR) as determined via Lumitrace plasma clearance. The primary endpoint of the phase 3 study is focused on showing statistical agreement between tGFR and the mGFR.

The TGFR Monitor displays information regarding the rate of decrease in Lumitrace fluorescence and how this changes over time. The monitoring of tGFR changes may prove clinically useful in the assessment of GFR at the point of care.

During a TGFR monitoring session the TGFR Monitor displays fluorescence data collected by the TGFR Sensor. The duration of a transdermal GFR monitoring session depends on a patient’s kidney function.

Transdermal GFR Across Skin Tones

The Transdermal GFR System (TGFR) has been designed to report a tGFR across the full range of human skin colors as quantified by the Fitzpatrick Skin Phototype (FSP).

Understanding Renal Function is a Significant Clinical Challenge

The MediBeacon TGFR proposed indications for use include the assessment of Glomerular Filtration Rate (GFR) in patients with impaired or normal renal function.

There are no limits to our thinking or what that thinking can accomplish.
Focus areas for
fluorescent agent-
based systems include:
Nephrology

Point of care assessment of renal function
-Learn More

Gastroenterology

Point of care gastrointestinal
permeability measurement
-Learn More

Ophthalmology

Fluorescent agent angiography
-Learn More

Surgery

Fluorescent tracer agent
use in surgery
-Learn More

United States
MediBeacon Inc.
425 N. New Ballas Road
Suite 100
St. Louis, MO 63141
P: (314) 269-5808

Germany
MediBeacon GmbH
Cubex41
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
P: +49 (0)621-150283-15

Greater China
(Commercial Partner)
Huadong Medicine Co., Ltd
Telephone: 4008-269-985
+86-(0)571-89908581
Zip: 310011
Address: No.866. Moganshan Road, Hangzhou, Zhejiang Province, China
Email: info@eastchinapharm.com

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*MediBeacon products are in various stages of clinical development and not yet approved for human use.

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