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In the Jove article it appears that the rat was quite sedated. Translated to mice: after isoflurane anesthesia, the mice will recovery quickly and move freely in the cage. Is this typically a problem, for example for recording, or removal of the Transdermal GFR Monitor by the animals?

It is true that the mice are more active, however, this is no problem for the measurements. Actually, the devices are more frequently used in mice than in rats. This is due the more complicated blood sampling in mice. This is especially true when GFR is to be measured in the same animal consecutively in short intervals (limited blood volume!). With our technique the same animal can be measured on a daily basis, as no blood sampling is required.

Of course, attachment of the device is a bit trickier in mice compared to rats in regard to size and activity of the animals. Therefore, Zoom training on the handling of the device in mice is offered to the costumer. After that it takes generally a week or two of training until the customers get the system running stable in their labs when working with mice.

Removal of the devices can be done without any anesthesia in both rats and mice. For mice the easiest way to do this is placing them on the cage lid offering the animals support whilst quickly removing the patch and tape.