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When you compare analysis by the transdermal GFR Monitor and traditional methods of bleeding followed by fluorescent reading in plasma using a spectrometer which technique will be preferable to analyze only subtle changes?

In our early papers1,2 the technique was compared to standard blood sample based techniques. A standard one-compartment model was used for evaluation of the GFR (t½). No significant difference between the blood methods and the transcutaneous method was detected. With our new algorithm3 we even reach the precision of constant infusion techniques. Furthermore, the technique was compared to creatinine clearance, BUN and other markers for renal impairment in a number of studies1,2,3. Especially in the near to normal GFR range the transcutaneous technique is much more sensitive than endogenous markers for renal function.

  1. Transcutaneous measurement of renal function in conscious mice Schreiber A, Shulhevich Y, Geraci S, Hesser J, Stsepankou D, Neudecker S, Koenig S, Heinrich R, Hoecklin F, Pill J, Friedemann J, Schweda F, Gretz N, Schock-Kusch D, “Transcutaneous measurement of renal function in conscious mice,” Am. J. Physiol. Renal Physiol. 303(5): F783-8, 2012.
  1. Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves Schock-Kusch D, Xie Q, Shulhevich Y, Hesser J, Stsepankou D, Sadick M, Koenig S, Hoecklin F, Pill J, Gretz N, “Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves,” Kidney Int. 79(11): 1254–8, 2011.
  1. Improved kinetic model for transcutaneous measurement of glomerular filtration rate in experimental animals. Friedemann, R. Heinrich, Y. Shulhevich, M. Raedle  J. Pill, D. Schock-Kusch, “Improved kinetic model for transcutaneous measurement of glomerular filtration rate in experimental animals,” Kidney int. In press, accepted for publication 14-Jul-2016 DOI: http://dx.doi.org/10.1016/j.kint.2016.07.024.