Regulation of Renal Cortical PPAR-alpha and Downstream Targets by Sodium Glucose Cotransporter, Type 2 Inhibition (SGLT2i) in High-Fat Fed Mice
Thursday, May 30th, 2024
Dexter Lee, Syed Khundmiri, Minsol Kim, Moshe Levi, Blythe Shepard, and Carolyn Ecelbarger. Physiology Volume 39, Issue S1 2024 May 21, https://doi.org/10.1152/physiol.2024.39.S1.1369
Upregulation of the Urotensin II System in Diabetic Kidney Disease Includes Urotensin II-Related Peptide
Thursday, May 30th, 2024
Olugbenga Michael, Praghalathan Kanthakumar, Hitesh Soni,Raji Lenin, Kumar Abhiram Jha, Rajashekhar Gangaraju, and Adebowale Adebiyi. Physiology Volume 39, Issue S1 2024 May 21, https://doi.org/10.1152/physiol.2024.39.S1.1002
Combination therapy with Lisinopril and Dapagliflozin rescues GFR decline and glomerular damage in the KKAy mouse model of diabetic kidney disease
Tuesday, May 28th, 2024
Arianne van Koppen, Simon Hinke, Tri Nguyen, Amélie Dendooven, Tzu-Ling Tseng, Wei-Chan Hsu, Ingeborg Bajema, Aswin Menke, Harry van Goor, Reinout Stoop, “Combination therapy with
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota–Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice
Tuesday, April 23rd, 2024
Zhaoyi Zhong, Yangting Zhang, Yuan Wei, Xiaona Li, Lisheng Ren, Yan Li, Xueqian Zhang, Chengyu Chen, Xueru Yin, Run Liu, and Qiuzhen Wang, “Fucoidan Improves
Nascent shifts in renal cellular metabolism, structure, and function due to chronic empagliflozin in pre-diabetic mice
Tuesday, March 12th, 2024
Blythe D. Shepard, Jennifer Chau, Ryan Kurtz, Avi Z Rosenberg, Pinaki Sarder, Samuel P Border, Brandon Ginley, Olga Rodriguez, Chris Albanese,Grace Knoer, Aarenee Greene, Aline
The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI
Monday, November 6th, 2023
Francesco Trepiccione, Anna Iervolino, Mariavittoria D’Acierno, Sabrina Siccardi, Vincenzo Costanzo, Donato Sardella, Luigi R. De La Motte, Luciano D’Apolito, Antonio Miele, Alessandra F. Perna, Giovanna
Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats
Tuesday, August 8th, 2023
Mandy Li, Levi Nguyen, Dorota Ferens, Iresha Spizzo, Yan Wang, Kate M. Denton, Mark Del Borgo, Ketav Kulkarni, Marie-Isabel Aguilar, Chengxue Helena Qin, Chrishan S.
Renal Renin is Upregulated by the Combination Treatment of Empagliflozin and RAS Blockade in Experimental Diabetic Nephropathy
Thursday, June 29th, 2023
Ander Vergara Arana, Carmen Llorens Cebria, Nerea Martos, Irene Martinez-Diaz, Frank Stein, Pamela Dominguez, Mireia Molina, Mandy Rettel, Begona Benito, Sheila Bermejo Garcia, Michael Paul
Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice
Thursday, March 23rd, 2023
Tong-sheng Huang, Teng Wu, Yan-di Wu, Xing-hui Li, Jing Tan, Cong-hui Shen, Shi-jie Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li1 & Wei-bin Cai, “Long-term statins
Blood pressure-independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes
Tuesday, March 7th, 2023
Edwyn O Cruz-López, Liwei Ren, Estrellita Uijl, Marian C Clahsen-van Groningen, Richard van Veghel, Ingrid M Garrelds, Oliver Domenig 6, Marko Poglitsch, Ivan Zlatev, Timothy
Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice
Monday, January 30th, 2023
Tong-sheng Huang, Teng Wu, Yan-di Wu, Xing-hui Li, Jing Tan, Cong-hui Shen, Shi-jie Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li & Wei-bin Cai,”Long-term statins administration
Blood pressure-independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes
Monday, January 16th, 2023
Edwyn O. Cruz-Lopez, Liwei Ren, Estrellita Uijl, Marian C. Clahsen-van Groningen4, Richard van Veghel, Ingrid M. Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Timothy Rooney,
The membrane-associated protein 17 (MAP17) is upregulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy
Tuesday, December 20th, 2022
Ander Vergara, Carmen Llorens, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper,
Blockade Ameliorates Cardiorenal Syndrome in the db/db Type 2 Diabetes Mouse Model
Wednesday, November 9th, 2022
Ander Vergara, Conxita Jacobs Cachá, Carmen Llorens Cebrià, Pamela Domínguez Báez, Nerea Martos, Irene Martínez Díaz, Sheila Bermejo, Michael P. Pieper, Begoña Benito, Maria Jose
Blood pressure-independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes
Thursday, September 22nd, 2022
Edwyn O. Cruz-López, Liwei Ren,Estrellita Uijl, Marian C. Clahsen-van Groningen, Richard van Veghel, Ingrid M. Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Timothy Rooney, Anne
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics
Monday, June 6th, 2022
Angelica Rodriguez-Niño, Diego O. Pastene*, Steffen A. Hettler, Jiedong Qiu, Thomas Albrecht, Srishti Vajpayee, Rossana Perciaccante, Norbert Gretz, Stephan J.L. Bakker, Bernhard K. Krämer, Benito
Effects of Combination of RTA nh404 and Dapagliflozin on Renal Involvement and Body Composition in Experimental Rat Model of Diabetic Kidney Disease
Thursday, February 24th, 2022
Fukami, K, Ota, K, Kodama, G, Yokota, Y, Shinohara, M, Ito, S, “Effects of Combination of RTA nh404 and Dapagliflozin on Renal Involvement and Body
Mechanism of the Canagliflozin-Induced Early Decline in GFR in Obese Diabetic Rats
Thursday, February 24th, 2022
Kodama, G, Kaida, Y, Ito, S, Ohta, K, Yokota, Y, Shinohara, M, Fukami, K, “Mechanism of the Canagliflozin-Induced Early Decline in GFR in Obese Diabetic
Salt loading with unilateral nephrectomy accelerates decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease
Thursday, February 3rd, 2022
Yuichi Shinozaki, Yuko Katayama, Fuminari Yamaguchi, Tomohisa Suzuki, Kana Watanabe, Kinuko Uno, Takahiro Tsutsui, Miki Sugimoto, Masami Shinohara, Katsuhiro Miyajima, Takeshi Ohta, “Salt loading with
Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models
Tuesday, December 28th, 2021
Philipp Tauber, Frederick Sinha, Raffaela S. Berger, Wolfram Gronwald, Katja Dettmer, Michaela Kuhn, Maximilian Trum, Lars S. Maier, Stefan Wagner, Frank Schwed, “Empagliflozin Reduces Renal
The Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Improves Left Ventricular Function in Preclinical Diabetic CKD
Tuesday, November 16th, 2021
Ixchel Q. Lima Posada, Yohan Stephan, Matthieu Soulié, Benjamin Bonnard, Roberto Palacios Ramirez, Lionel Nicol, Peter Kolkhof, Paul Mulder, Frederic Jaisser, “The Nonsteroidal Mineralocorticoid Receptor
Loss of Functional SCO2 Attenuates Oxidative Stress in Diabetic Kidney Disease
Saturday, October 30th, 2021
Nehaben A. Gujarati, Alexandra R. Leonardo, Jessica M. Vasquez, Yiqing Guo, Bismark O. Frimpong, Elbek Fozilov, Monica P. Revelo, Ilse S. Daehn, John C. He,
Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease
Thursday, July 29th, 2021
Mette V. Østergaard, Thomas Secher, Michael Christensen, Casper Gravesen Salinas, Urmas Roostalu, Jacob Lercke Skytte, Ida Rune, Henrik H. Hansen, Jacob Jelsing, Niels Vrang, and
The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)
Thursday, June 24th, 2021
Aowen Zhuang1, Felicia Y. T. Yap, Danielle J. Borg, Domenica McCarthy, Amelia Fotheringham, Sherman Leung, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin
Glomerular hyperfiltration with hyperglycemia in the spontaneously diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model
Wednesday, March 24th, 2021
R Sano, Y Ishii, M Yamanaka, Y Yasui, Y Kemmochi, F Kuroki, M Sugimoto, S Fukuda, T Sasase, K Miyajima, D Nakae, T Ohta, “Glomerular
Glomerular hyperfiltration with hyperglycemia in the Spontaneously Diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model
Monday, January 25th, 2021
Ryuhei Sano, Yukihito Ishi, Masao Yamanaka1, Yuzo Yasui, Yusuke Kemmochi, Fuko Kuroki, Miki Sugimoto, Sumiaki Fukuda, Tomohiko Sasase, Katsuhiro Miyajima, Dai Nakae, Takeshi Ohta, “Glomerular
Drug Testing for Residual Progression of Diabetic Kidney Disease in Mice Beyond Therapy with Metformin, Ramipril, and Empagliflozin
Monday, July 13th, 2020
Manga Motrapu, Monika Katarzyna Swiderska, Irene Mesas, Julian Aurelio Marschner, Yutian Lei, Laura Martinez Valenzuela, Jia Fu, Kyung Lee, Maria Lucia Angelotti, Giulia Antonelli, Paola
The Effects of Chronic Dapagliflozin Treatment on the Renal Microvasculature in a Rat Model of Type 2 Diabetes
Wednesday, June 10th, 2020
Connie Ow, Vijayakumar Sukumaran, Jennifer Ngo, Cheng Kun Du, Akihiro Fujiwara, Hirotsugu Tsuchimochi, Hiroshi Hosoda, Roger Evans, James Pearson, “The Effects of Chronic Dapagliflozin Treatment
Revisiting Experimental Models of Diabetic Nephropathy
Tuesday, June 2nd, 2020
Anna Giralt-López, Mireia Molina-Van den Bosch, Ander Vergara, Clara García-Carro, Daniel Seron, Conxita Jacobs-Cachá, and Maria José Soler, “Revisiting Experimental Models of Diabetic Nephropathy,” International
Soluble (pro)renin receptor treats metabolic syndrome in mice with diet-induced obesity via interaction with PPARγ
Wednesday, April 15th, 2020
Fei Wang, Renfei Luo, Chang-Jiang Zou, Shiying Xie, Kexin Peng, Long Zhao, Kevin T. Yang, Chuanming Xu, and Tianxin Yang, “Soluble (pro)renin receptor treats metabolic
Rapid Progression of Glomerulosclerosis due to Concurrent Diabetes and Hypertension Correlates with Podocyte Damage Shown by Expansion Microscopy
Tuesday, December 17th, 2019
Yalcin Kuzay, Euan Clark, Sara Medina Balbuena, Benito Yard, John Mullins, Wilhelm Kriz, Hermann-Josef Gröne, Sigrid C. Hoffmann, “Rapid Progression of Glomerulosclerosis due to Concurrent
Restricted Access Matching Human Unilateral AKI, a Reverse Translational Approach to Investigate Kidney Recovery after Ischemia
Friday, December 13th, 2019
Danielle E. Soranno, Hyo-Wook Gil, Lara Kirkbride-Romeo, Christopher Altmann, John R. Montford, Haichun Yang, Ani Levine, Jane Buchanan and Sarah Faubel, “Restricted Access Matching Human
Whole-Kidney 3D Imaging and Transcriptome Assessment in the UNxdb/db Mouse Model of Diabetic Nephropathy
Wednesday, December 4th, 2019
Diabetic Nephropathy Frederikke E. Sembach, Brandon B. Boland, Lisbeth N. Fink, Urmas Roostalu, Jacob L. Skytte, Thomas Secher, Keld Fosgerau, Niels Vrang, Jacob Jelsing, Jacob
The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease
Tuesday, December 3rd, 2019
Masahiro Eriguchi, Ellen A. Bernstein, Luciana C. Veiras, Zakir Khan, Duo Yao Cao, Sebastien Fuchs, Alicia A. McDonough, Jorge E. Toblli, Romer A. Gonzalez-Villalobos, Kenneth
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
Tuesday, November 26th, 2019
Dagmar Schumacher, Jakob Morgenstern, Yoko Oguchi, Nadine Volk, Stefan Kopf, Jan Benedikt Groener, Peter Paul Nawroth, Thomas Fleming, Marc Freichel, “Compensatory mechanisms for methylglyoxal detoxification
Dapagliflozin Reduces Glomerular Hyperfiltration and Improves Urine Parameters in db/db Mice on High Protein Diet: A 4-week Model of Diabetic Nephropathy
Monday, November 25th, 2019
Francois Briand, Sisse A. Nørgaard, Noémie Burr, Clément Costard, Emmanuel Brousseau, Nourdine Faresse, Fredrik Wolfhagen Sand, Thierry Sulpice, “Dapagliflozin Reduces Glomerular Hyperfiltration and Improves Urine
Glomerular Injury and Progressive Cardiac Dysfunction in the Obese ZSF1 Rat, a New Model of Diabetic Nephropathy and Heart Failure with Preserved Ejection Fraction
Thursday, November 14th, 2019
Elyse Di marco, Erik Michaëlsson, Charlotte Ericson, Margareta Behrendt, Maria Stromstedt, Magnus Soderberg, Johannes Wikstrom, Anna Granqvist, “Glomerular Injury and Progressive Cardiac Dysfunction in the
Losartan improves renal function and pathology in obese ZSF-1 rats
Friday, November 8th, 2019
Zhi Su, Deborah Widomski, Artur Nikkel, Laura Lets, Marian Namovic, Diana Donnelly-Roberts, Murall Gopalakrishnan, Steve McGaraughty, “Losartan improves renal function and pathology in obese ZSF-1
An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model
Sunday, October 13th, 2019
Xiaoyan Zhou, Ji Zhang, Robin Haimbach, Wei Zhu, Rosemary Mayer-Ezell, Margarita Garcia-Calvo, Elizabeth Smith, Olga Price, Yanquig Kan, Emanuel Zycband, Yonghua Zhu, Maarten Hoek, Jason
Renal Tubular ACE-Mediated Tubular Injury is The Major Contributor to Microalbuminuria in Early Diabetic Nephropathy
Friday, October 4th, 2019
Masahiro Eriguchi, Mercury Lin, Michifumi Yamashita, Tuantuan V. Zhao, Zakir Khan, Ellen A. Bernstein, Susan B Gurley, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein, Jorge Fernando
Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes
Tuesday, October 1st, 2019
Micheal S. Ward, Nicole B. Flemming, Linda A. Gallo, Amelia K. Fotheringham, Domenica A. McCarthy, Aowen Zhuang, Peter H. Tang, Danielle J. Borg1, Hannah Shaw,
Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring
Monday, September 16th, 2019
Hokke S., Arias N., Armitage J.A., Puelles V.G., Fong K., Geraci S., Gretz N., Bertram J.F., Cullen-McEwen L.A., “Maternal glucose intolerance reduces offspring nephron endowment
Maternal Glucose Intolerance Reduces Offspring Nephron Endowment and Increases Glomerular Volume in Adult Offspring
Saturday, September 14th, 2019
Hokke S, Arias N, Armitage JA, Puelles VG, Fong K, Geraci S, Gretz N, Bertram JF, Cullen-McEwen LA, “Maternal Glucose Intolerance Reduces Offspring Nephron Endowment
Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice
Tuesday, September 10th, 2019
Gallo LA, Ward MS, Fotheringham AK, Zhuang A, Borg DJ, Flemming NB, Harvie BM, Kinneally TL, Yeh SM, McCarthy DA, Koepsell H, Vallon V, Pollock
PBI-4425, A novel anti-inflamantory/fibrotic compound, improves kidney function and glomerular integrity in the diabetic DB/DB mouse mode
Sunday, September 8th, 2019
Lyne Gagnon, Kathy Hince, François Sarra-Bournet, Liette Gervais, Alexandra Felton, Alexandre Laverdure, William Gagnon, Martin Leduc, Lilianne Geerts, Pierre Laurin, Brigitte Grouix, “PBI-4425, A novel
A Potent Pan-AMPK Activator Improves Renal Structure and Function in the ZSF-1 Rat Model of Diabetic Nephropathy
Friday, September 6th, 2019
Hoek M., Zhou X., Haimbach R. E., Muise E., Ma L-J, Price O., Forrest G.M., Herath K., Zycband E., Ruben Z., Zhu Y., Pinto S.,
Renal Olfactory Receptor 1393 Contributes to Glucose Reabsorption
Thursday, September 5th, 2019
Shepard B. D., Cheval L., Zita P. L., Firestein S., Koepsel H., Doucet A., Pluznick J. L., “Renal Olfactory Receptor 1393 Contributes to Glucose Reabsorption,”
Renal Tubular ACE Affects Microalbuminuria in Early Diabetic Nephropathy
Wednesday, September 4th, 2019
Eriguchi M., Giani J.F., Lin M.Y., Zhao T., Khan Z., Bernstein E.A., Shen X., Gonzalez-Villalobos R.A., Bernstein K.E., “Renal Tubular ACE Affects Microalbuminuria in Early
A Longitudinal Study on Kidney Function, Pathology, and Multiple Urinary Biomarkers in ZSF1 Rat Model of Type II Diabetic Nephropathy
Wednesday, August 21st, 2019
Z. Su, D. Widomski, M. T. Namovic, D. L. Donnelly‑Roberts, L. Leys, K. Salte, A. L. Nikkel, L. Olson, J. Ma, T. A.Esbenshade, S. McGaraughty,
